BDBM50621435 CHEMBL5483060

SMILES CC1N(CCCN(CC(=O)NCCN(C)C(=O)CCc2cc(Cl)c(Oc3ccsc3C(=O)N3CCN(C4CC4)c4ccccc34)cc2Cl)C1=O)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F

InChI Key InChIKey=FSMBVUGCZNRZOC-UHFFFAOYSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50621435   

TargetG-protein coupled bile acid receptor 1(Mouse)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50621435(CHEMBL5483060)
Affinity DataEC50:  6nMAssay Description:Agonist activity at mouse TGR5 expressed in human HEK293 cells co-expressing CRE-driven luciferase reporter gene assessed as luciferase activity incu...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50621435(CHEMBL5483060)
Affinity DataEC50:  15nMAssay Description:Agonist activity at human TGR5 expressed in human HEK293 cells co-expressing CRE-driven luciferase reporter gene assessed as luciferase activity incu...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Mouse)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50621435(CHEMBL5483060)
Affinity DataIC50: 224nMAssay Description:Inhibition of mouse serum DPP4 assessed as cleavage of substrate by measuring AMC release using Gly-Pro-AMC as substrate by fluorescence based microp...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed