BDBM50621577 CHEMBL4779280

SMILES CC(C)S(=O)(=O)c1ccc2c(c1)c(ccn2)Nc3ccc4c(c3)ncs4

InChI Key InChIKey=ZCDBTQNFAPKACC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50621577   

TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50621577(CHEMBL4779280)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of recombinant human RIP3 kinase activity by ADP-glo assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50621577(CHEMBL4779280)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of recombinant human RIPK3 (2-328) residues expressed in baculovirus by ADP-glo assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50621577(CHEMBL4779280)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of recombinant human RIPK3 (2-328) residues expressed in baculovirus by FP assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50621577(CHEMBL4779280)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of recombinant human RIP3 kinase domain (1 to 328 residues) expressed in baculovirus expression system by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50621577(CHEMBL4779280)
Affinity DataIC50: 2nMAssay Description:Inhibition of N-terminal polyHis-tagged human RIPK2 (8 to 310 residues) expressed in Sf9 cells using MBP as substrate preincubated for 15 mins follow...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50621577(CHEMBL4779280)
Affinity DataIC50: 4nMAssay Description:Inhibition of RIPK2-mediated NF-kappaB signalling in MDP-treated human THP-1 cells preincubated for 30 mins followed by MDP addition measured after 2...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50621577(CHEMBL4779280)
Affinity DataIC50: 9nMAssay Description:Inhibition of RIPK2-mediated NF-kappaB signalling in C14-TriLAN-Gly-treated human THP-1 cells preincubated for 30 mins followed by C14-TriLAN-Gly add...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50621577(CHEMBL4779280)
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant RIPK3 using MBP as substrate preincubated for 15 mins followed by substrate addition and measured after 120 mins in p...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50621577(CHEMBL4779280)
Affinity DataIC50: 77nMAssay Description:Inhibition of N-terminal polyHis-tagged human RIPK3 (1 to 307 residues) expressed in Sf9 cells using MBP as substrate preincubated for 15 mins follow...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Korea University

Curated by ChEMBL
LigandPNGBDBM50621577(CHEMBL4779280)
Affinity DataIC50: 929nMAssay Description:Inhibition of human recombinant RIPK1 using MBP as substrate preincubated for 15 mins followed by substrate addition and measured after 120 mins in p...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed