BDBM50622405 CHEMBL5408388::US20260015328, Compound TD-641

SMILES CN(C)CCCOc1ccc(cn1)-c1ccc2ncn(-c3ccc4CCN(c4c3)S(=O)(=O)C3CC3)c2n1

InChI Key InChIKey=MSBVAOCTAUZSGY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50622405   

TargetSerine-protein kinase ATM(Human)
Eberhard Karls University of Tubingen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50622405BDBM50622405(CHEMBL5408388 | US20260015328, Compound TD-641)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of ATM kinase in human A549 cells in presence of etoposide by ICW assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetSerine-protein kinase ATM(Human)
Eberhard Karls University of Tubingen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50622405BDBM50622405(CHEMBL5408388 | US20260015328, Compound TD-641)
Affinity DataIC50: 0.410nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
5/28/2026
Entry Details
US Patent

TargetSerine-protein kinase ATM(Human)
Eberhard Karls University of Tubingen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50622405BDBM50622405(CHEMBL5408388 | US20260015328, Compound TD-641)
Affinity DataIC50: 0.410nMAssay Description:Inhibition of human ATM kinase using p53 as substrate by FRET assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed