BDBM50623164 CHEMBL5426067

SMILES COc1ncc(cc1NS(C)(=O)=O)-c1ccc2ncc(C#N)c(N3CCOCC3)c2c1

InChI Key InChIKey=SEBHGEYNGDJWAR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50623164   

TargetSerine/threonine-protein kinase mTOR(Human)
University of Calabria

Curated by ChEMBL
LigandPNGBDBM50623164(CHEMBL5426067)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of N-terminal FLAG-tagged recombinant human mTOR (1362 to end residues) incubated for 60 mins in presence of ATP by LANCE Ultra phosphatas...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50623164(CHEMBL5426067)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of N-terminal His-tagged recombinant human P13Kalpha incubated for 60 mins in presence of ATP by kinase-glo luminescence assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50623164(CHEMBL5426067)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate measured after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM50623164(CHEMBL5426067)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of full length His-tagged recombinant human P13Kgamma expressed in baculovirus incubated for 60 mins in presence of ATP by kinase-glo lumi...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed