BDBM50623616 CHEMBL5430810

SMILES [H][C@]12C[C@]([H])(CN(C1)c1ccc(cn1)-c1cc(OCC(C)(C)O)cn3ncc(C#N)c13)N2Cc1ccc(OC)nc1

InChI Key InChIKey=XIIOFHFUYBLOLW-UHFFFAOYSA-N

Data  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50623616   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Jinan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50623616BDBM50623616(CHEMBL5430810)
Affinity DataKd:  0.300nMAssay Description:Binding affinity to RET (unknown origin) assessed as dissociation constant in presence of ATP by FRET based Z'-Lyte assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetCoiled-coil domain-containing protein 6(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50623616BDBM50623616(CHEMBL5430810)
Affinity DataIC50: 1.60nMAssay Description:Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Jinan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50623616BDBM50623616(CHEMBL5430810)
Affinity DataIC50: 3.30nMAssay Description:Agonist activity at human PPARalpha receptor by cell based transient transfection assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Jinan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50623616BDBM50623616(CHEMBL5430810)
Affinity DataIC50: 5.20nMAssay Description:Agonist activity at human PPARalpha receptor by cell based transient transfection assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Jinan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50623616BDBM50623616(CHEMBL5430810)
Affinity DataIC50: 88nMAssay Description:Agonist activity at mouse PPARalpha receptor by cell based transient transfection assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetProtein cereblon(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50623616BDBM50623616(CHEMBL5430810)
Affinity DataIC50: 5.00E+4nMAssay Description:Displacement of radioligand from human recombinant adenosine A3 receptor at 21 degC after 60 mins by cell-based microplate scintillation countingMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetProtein cereblon(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50623616BDBM50623616(CHEMBL5430810)
Affinity DataIC50: 5.00E+4nMAssay Description:Displacement of radioligand from human recombinant adenosine A3 receptor at 21 degC after 60 mins by cell-based microplate scintillation countingMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed