BDBM50625270 CHEMBL5428294::US20250243227, Compound 12

SMILES NCC[C@@H]1O[C@H]([C@@H](O)[C@H](O)[C@H]1O)C(O)=O

InChI Key InChIKey=OFSZGQLGRVXQMI-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50625270   

TargetAlpha-L-iduronidase(Human)
Genomics Research Center

Curated by ChEMBL
LigandPNGBDBM50625270(CHEMBL5428294 | US20250243227, Compound 12)
Affinity DataKi:  4.00E+3nMAssay Description:Inhibition of human recombinant alpha-L-iduronidase using 4-methylumbelliferyl-alpha-iduronide as fluorogenic substrate assessed as inhibition consta...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetAlpha-L-iduronidase(Human)
Genomics Research Center

Curated by ChEMBL
LigandPNGBDBM50625270(CHEMBL5428294 | US20250243227, Compound 12)
Affinity DataKi:  4.00E+3nM IC50: 6.70E+3nMAssay Description:The compounds of Example 1 were evaluated on their inhibitory potential against rh-α-IDUA, and their apparent IC50 values were determined by using th...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
11/13/2025
Entry Details
Go to US Patent

TargetAlpha-L-iduronidase(Human)
Genomics Research Center

Curated by ChEMBL
LigandPNGBDBM50625270(CHEMBL5428294 | US20250243227, Compound 12)
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of human recombinant alpha-L-iduronidase using 4-methylumbelliferyl-alpha-iduronide as fluorogenic substrateMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed