BDBM50625569 CHEMBL5415214

SMILES CCc1nc(N)nc(N)c1Cc1cccc(c1)-c1cccc(c1)C(=O)OC

InChI Key InChIKey=LZUNMUXBUPPNFI-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50625569   

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium Falciparum)
National Center for Genetic Engineering and Biotechnology (BIOTEC)

Curated by ChEMBL
LigandPNGBDBM50625569(CHEMBL5415214)
Affinity DataKi:  0.210nMAssay Description:Inhibition of wild type Plasmodium falciparum DHFR using DHF as substrate assessed as inhibition constant in presence of NADPH by UV-Vis spectrometry...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDihydrofolate reductase(Human)
National Center for Genetic Engineering and Biotechnology (BIOTEC)

Curated by ChEMBL
LigandPNGBDBM50625569(CHEMBL5415214)
Affinity DataKi:  19nMAssay Description:Inhibition of human DHFR using DHF as substrate assessed as inhibition constant in presence of NADPH by UV-Vis spectrometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed