BDBM50627128 CHEMBL5404107

SMILES C[C@H](NC1(C)CCC1)c1cc2C(=O)N(Cc2c(c1)C(F)(F)F)c1cccc(c1)[C@H](C1COC1)c1nncn1C

InChI Key InChIKey=ITCYMXGHPXIVGP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50627128   

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50627128(CHEMBL5404107 | US12187709, Compound 442)
Affinity DataIC50: 4nMAssay Description:Inhibition of biotin-tagged Cbl-b (unknown origin) assessed as reduction in LCK ubiquitination using His-LCK as substrate preincubated for 60 mins fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase CBL-B(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50627128(CHEMBL5404107 | US12187709, Compound 442)
Affinity DataKd:  180nMAssay Description:Table 4: Chaser assay utilize a single cycle kinetics SPR experiment with a contact time of 120 seconds, a flow rate of 50 μl/min and a dissociation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent

LigandPNGBDBM50627128(CHEMBL5404107 | US12187709, Compound 442)
Affinity DataIC50: 260nMAssay Description:Table 3: Compounds were 3-fold serially diluted in DMSO in a 384-well polypropylene plate (#P-05525-BC; Labcyte) to generate a source plate with 10 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent

LigandPNGBDBM50627128(CHEMBL5404107 | US12187709, Compound 442)
Affinity DataIC50: 2.80E+3nMAssay Description:Table 3: Compounds were 3-fold serially diluted in DMSO in a 384-well polypropylene plate (#P-05525-BC; Labcyte) to generate a source plate with 10 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandPNGBDBM50627128(CHEMBL5404107 | US12187709, Compound 442)
Affinity DataKd:  3.30E+3nMAssay Description:Table 4: Chaser assay utilize a single cycle kinetics SPR experiment with a contact time of 120 seconds, a flow rate of 50 μl/min and a dissociation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent