BDBM50627870 CHEMBL5424497

SMILES CNC(=O)c1nnc(NC(=O)C2CC2)c2[nH]c(cc12)-c1ccc(N)cc1OC

InChI Key InChIKey=FGFGLAJKHODMGZ-UHFFFAOYSA-N

Data  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50627870   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50627870(CHEMBL5424497)
Affinity DataKd:  0.0190nMAssay Description:Binding affinity to human recombinant TYK2 (556 to 871 residues) incubated for 10 hrs by microplate reader based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50627870(CHEMBL5424497)
Affinity DataKd:  0.520nMAssay Description:Binding affinity to JAK1 JH2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50627870(CHEMBL5424497)
Affinity DataKd:  190nMAssay Description:Binding affinity to wild type JAK2 JH2 (unknown origin) assessed as dissociation constant by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50627870(CHEMBL5424497)
Affinity DataKd:  300nMAssay Description:Binding affinity to TYK2 JH1 domain (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed