BDBM50628031 CHEMBL5414358

SMILES O=C(N1CCN2CCC1CC2)n1nc(-c2ccc(F)cc2)c2c1[C@H]1C[C@H]1C2

InChI Key InChIKey=ZSSKOIZKSZYGNN-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50628031   

TargetCeramide glucosyltransferase(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50628031BDBM50628031(CHEMBL5414358 | US20250026762, Compound 11)
Affinity DataEC50:  0.100nMAssay Description:Inhibition of GCS in human A-375 cell golgi body using C6-ceramide and UDP-glucose as substrate assessed as reduction in UDP production preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCeramide glucosyltransferase(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50628031BDBM50628031(CHEMBL5414358 | US20250026762, Compound 11)
Affinity DataEC50:  0.100nMAssay Description:Using Promega's UDP-Glo™ Glycosyltransferase assay kit (Promega Corporation, Madison, WI, USA (Promega)), GCS activity was indirectly measured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2025
Entry Details
US Patent