BDBM50628107 CHEMBL5420187

SMILES [2H]C([2H])([2H])NC(=O)c1nnc(Nc2ccc(cn2)N2CCOCC2)cc1Nc1nccc(c1OC)-c1ncc(F)cn1

InChI Key InChIKey=XTJXYCLHGIQOPR-FIBGUPNXSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50628107   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50628107(CHEMBL5420187)
Affinity DataIC50: 0.600nMAssay Description:Displacement of fluorescein-labeled kinase tracer from His-TVMV-TYK2 JH2 (575 to 869 residues) (unknown origin) measured after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50628107(CHEMBL5420187)
Affinity DataIC50: 52nMAssay Description:Inhibition of TYK2 JH2 domain in human whole blood assessed as reduction in IFNalpha-induced STAT5 phosphorylation preincubated for 1 hr followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed