BDBM50628589 CHEMBL4210329

SMILES C(c1ccccc1)n1nnc2c(Sc3nc4ccccc4o3)ncnc12

InChI Key InChIKey=HZSOKHVVANONPV-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50628589   

TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50628589BDBM50628589(CHEMBL4210329)
Affinity DataIC50: 100nMAssay Description:Inhibition of human NOX2 transfected in PLB-985 cells assessed as PMA-induced hydrogen peroxide pre-incubated for 10 and measured after 15 mins by Am...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50628589BDBM50628589(CHEMBL4210329)
Affinity DataIC50: 304nMAssay Description:Inhibition of human NOX2 extracted from PLB-985 cell membrane incubated for 1 hr in presence of PMA by cytochrome c reduction assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetNADPH oxidase 1(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50628589BDBM50628589(CHEMBL4210329)
Affinity DataIC50: 500nMAssay Description:Inhibition of human NOX1 transfected in CHO cells assessed as PMA-induced hydrogen peroxide pre-incubated for 10 and measured after 15 mins by Amplex...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDual oxidase 1(Homo sapiens)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50628589BDBM50628589(CHEMBL4210329)
Affinity DataIC50: 700nMAssay Description:Inhibition of human DUOX1 transfected in HEK cells assessed as PMA-induced hydrogen peroxide production preincubated for 15 mins and measured after 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50628589BDBM50628589(CHEMBL4210329)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human NOX2 extracted from PLB-985 cell membrane incubated for 1 hr in presence of NADPH by MCLA based UV-vis spectrophotometer analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetNADPH oxidase 5(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50628589BDBM50628589(CHEMBL4210329)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of human NOX5 extracted from HEK293F cell membrane incubated for 1 hr in presence of NADPH by amplex red/horseradish peroxidase staining b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetNADPH oxidase 5(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50628589BDBM50628589(CHEMBL4210329)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of human NOX5 transfected in HEK cells assessed as PMA-induced hydrogen peroxide production pre-incubated for 10 mins and measured after 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDual oxidase 2(Homo sapiens)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50628589BDBM50628589(CHEMBL4210329)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of human DUOX2 transfected in HEK cells assessed as PMA-induced hydrogen peroxide production preincubated for 15 mins and measured after 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50628589BDBM50628589(CHEMBL4210329)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of human NOX2 incubated for 1 hr in presence of NADPH by UV-vis spectrophotometer analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetNADPH oxidase 4(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50628589BDBM50628589(CHEMBL4210329)
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of human NOX4 transfected in HEK293-T-REx cells assessed as PMA-induced hydrogen peroxide production pre-incubated for 10 mins and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNADPH oxidase 4(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50628589BDBM50628589(CHEMBL4210329)
Affinity DataIC50: 1.23E+4nMAssay Description:Inhibition of human NOX4 extracted from HEK293F cell membrane incubated for 1 hr in presence of NADPH by amplex red/horseradish peroxidase staining b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetNADPH oxidase 3(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50628589BDBM50628589(CHEMBL4210329)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human NOX3 transfected in HEK293-T-REx cells assessed as PMA-induced hydrogen peroxide production pre-incubated for 10 mins and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNADPH oxidase 1(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50628589BDBM50628589(CHEMBL4210329)
Affinity DataIC50: 7.26E+4nMAssay Description:Inhibition of human NOX1 extracted from HEK293F cell membrane incubated for 1 hr in presence of NADPH by amplex red/horseradish peroxidase staining b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed