BDBM50629135 CHEMBL5413496

SMILES Cc1ccccc1Nc1ncc(cc1NC(=O)c1cc(F)cc(c1)C(F)(F)F)C(=O)Nc1ccncc1

InChI Key InChIKey=GKNDXQBDYPJJPO-UHFFFAOYSA-N

Data  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50629135   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Usona Institute

Curated by ChEMBL

LigandBDBM50629135(CHEMBL5413496 | US20250090540, Example I-234)Copy SMILESCopy InChI

Affinity DataIC50: 100nMAssay Description:Inhibition of PIK3CA (unknown origin) using diC8-PIP2 as substrate preincubated for 30 mins followed by substrate addition and measured after 60 mins...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/19/2024
Entry Details
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Usona Institute

Curated by ChEMBL

LigandBDBM50629135(CHEMBL5413496 | US20250090540, Example I-234)Copy SMILESCopy InChI

Affinity DataIC50: 300nMAssay Description:Compounds to be assayed were plated in 16 doses of 1:2 serial dilutions (20 nL volume each well) on a 1536-well plate, and the plate warmed to room t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
9/28/2021
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL