BDBM50629513 CHEMBL5397998::US20250282782, Compound 183

SMILES Cc1nc(N2CCC3(Cc4ncccc4[C@H]3N)CC2)c2ccnn2c1-c1ccc2OCCOc2c1

InChI Key InChIKey=XQGWBLQMOKYLFS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50629513   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50629513(CHEMBL5397998 | US20250282782, Compound 183)
Affinity DataIC50: 3nMAssay Description:Inhibition of full length N-terminal his6-tagged human recombinant SHP2 phosphatase activity using DiFMUP as substrate incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50629513(CHEMBL5397998 | US20250282782, Compound 183)
Affinity DataIC50: 3nMAssay Description:Inhibition of SHP2 phosphatase activity was evaluated using human recombinant 6His-Nterm (SEQ ID NO: 1) SHP2 full-length (Thr2-Arg593, R&D system), N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2025
Entry Details
Go to US Patent