BDBM50629545 CHEMBL5420257

SMILES Cc1ccc(NC(=O)c2ccc(cc2)-c2cccc(c2)C(F)(F)F)cc1C(=O)Nc1cnc(Nc2cccc(N)c2)nc1

InChI Key InChIKey=MGJRUWHJBSOWPN-UHFFFAOYSA-N

Data  3 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50629545   

TargetTyrosine-protein kinase Blk(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50629545(CHEMBL5420257)
Affinity DataEC50:  49nMAssay Description:Induction of ubiquitin proteasomal system dependent BLK degradation in human Ramos cells measured after 12 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase Blk(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50629545(CHEMBL5420257)
Affinity DataEC50:  95nMAssay Description:Induction of ubiquitin proteasomal system dependent BLK degradation of BLK in human DOHH-2 cells by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase Blk(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50629545(CHEMBL5420257)
Affinity DataEC50:  230nMAssay Description:Induction of ubiquitin proteasomal system dependent BLK degradation of BLK in human SU-DHL-6 cells by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase Blk(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50629545(CHEMBL5420257)
Affinity DataEC50:  270nMAssay Description:Induction of ubiquitin proteasomal system dependent BLK degradation of BLK in human SU-DHL-4 cells by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase Blk(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50629545(CHEMBL5420257)
Affinity DataIC50: 443nMAssay Description:Inhibition of N-terminal GST tagged BLK (1 to 505 end residues) (unknown origin) expressed in Sf21insect cells by time resolved fluorescence based as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50629545(CHEMBL5420257)
Affinity DataIC50: 2.56E+3nMAssay Description:Inhibition of full length N-terminal GST tagged BTK (2 to 659 end residues) (unknown origin) expressed in Sf21insect cells by time resolved fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50629545(CHEMBL5420257)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of SYK phosphorylation in human Ramos cells incubated for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed