BDBM50629818 CHEMBL5410160

SMILES C=CC(=O)Nc1ccc(-c2nc(Nc3cc(C)[nH]n3)c3ccc(N4CCN(C)CC4)cc3n2)cc1

InChI Key InChIKey=VXYSKFCQDLEGDW-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50629818   

TargetAurora kinase A(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50629818BDBM50629818(CHEMBL5410160)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of recombinant human Aurora A (1 to 403 residues) expressed in Escherichia coli using STK-substrate 2-biotin as substrate incubated for 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetAurora kinase A(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50629818BDBM50629818(CHEMBL5410160)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of recombinant human Aurora A (1 to 403 residues) expressed in Escherichia coli using STK-substrate 2-biotin as substrate incubated for 40...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetAurora kinase A(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50629818BDBM50629818(CHEMBL5410160)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of recombinant human Aurora A (1 to 403 residues) expressed in Escherichia coli using FAM-labeled peptide as substrate preincubated for 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetAurora kinase A(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50629818BDBM50629818(CHEMBL5410160)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of recombinant human Aurora A (1 to 403 residues) expressed in Escherichia coli using STK-substrate 2-biotin as substrate incubated for 40...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetAurora kinase A(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50629818BDBM50629818(CHEMBL5410160)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of recombinant human Aurora A (1 to 403 residues) expressed in Escherichia coli using STK-substrate 2-biotin as substrate incubated for 60...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetAurora kinase A(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50629818BDBM50629818(CHEMBL5410160)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of recombinant human Aurora A (1 to 403 residues) expressed in Escherichia coli using STK-substrate 2-biotin as substrate incubated for 60...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetAurora kinase A(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50629818BDBM50629818(CHEMBL5410160)
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant human Aurora A (1 to 403 residues) expressed in Escherichia coli using STK-substrate 2-biotin as substrate incubated for 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetAurora kinase A(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50629818BDBM50629818(CHEMBL5410160)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of recombinant human Aurora A (1 to 403 residues) expressed in Escherichia coli using STK-substrate 2-biotin as substrate incubated for 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetAurora kinase A(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50629818BDBM50629818(CHEMBL5410160)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of recombinant human Aurora A (1 to 403 residues) expressed in Escherichia coli using STK-substrate 2-biotin as substrate incubated for 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetAurora kinase A(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50629818BDBM50629818(CHEMBL5410160)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of recombinant human Aurora A (1 to 403 residues) expressed in Escherichia coli using STK-substrate 2-biotin as substrate incubated for 40...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetAurora kinase A(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50629818BDBM50629818(CHEMBL5410160)
Affinity DataIC50: 8.10nMAssay Description:Inhibition of recombinant human Aurora A (1 to 403 residues) expressed in Escherichia coli using STK-substrate 2-biotin as substrate incubated for 60...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetAurora kinase A(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50629818BDBM50629818(CHEMBL5410160)
Affinity DataIC50: 8.30nMAssay Description:Inhibition of recombinant human Aurora A (1 to 403 residues) expressed in Escherichia coli using STK-substrate 2-biotin as substrate incubated for 40...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetAurora kinase A(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50629818BDBM50629818(CHEMBL5410160)
Affinity DataIC50: 23nMAssay Description:Inhibition of recombinant human Aurora A (1 to 403 residues) expressed in Escherichia coli using STK-substrate 2-biotin as substrate incubated for 60...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed