BDBM50629942 CHEMBL5424599

SMILES OC(=O)CCNC(=S)NCCCNc1nc(Nc2ccccc2)nc(Nc2ccccc2Cl)n1

InChI Key InChIKey=GYRJFKFZTHWZOR-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50629942   

LigandPNGBDBM50629942(CHEMBL5424599)
Affinity DataIC50: 2.27E+3nMAssay Description:Inhibition of human recombinant SIRT5 (34 to 269 residues) using Ac-Leu-Gly-Ser-Lys (Su)-AMC as fluorogenic substrate incubated for 2 hrs in presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50629942(CHEMBL5424599)
Affinity DataIC50: 3.21E+3nMAssay Description:Competitive inhibition of human recombinant SIRT5 (34 to 269 residues) incubated for 2 hrs in presence of 11 uM of fluorogenic substrate Ac-Leu-Gly-S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50629942(CHEMBL5424599)
Affinity DataIC50: 3.35E+3nMAssay Description:Inhibition of human recombinant SIRT5 (34 to 269 residues) using Ac-Leu-Gly-Ser-Lys (Su)-AMC as fluorogenic substrate incubated for 2 hrs in presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50629942(CHEMBL5424599)
Affinity DataIC50: 4.05E+3nMAssay Description:Inhibition of human recombinant SIRT5 (34 to 269 residues) using Ac-Leu-Gly-Ser-Lys (Su)-AMC as fluorogenic substrate incubated for 2 hrs in presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50629942(CHEMBL5424599)
Affinity DataIC50: 4.68E+3nMAssay Description:Inhibition of human recombinant SIRT5 (34 to 269 residues) using Ac-Leu-Gly-Ser-Lys (Su)-AMC as fluorogenic substrate incubated for 2 hrs in presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50629942(CHEMBL5424599)
Affinity DataIC50: 5.38E+3nMAssay Description:Inhibition of human recombinant SIRT5 (34 to 269 residues) using Ac-Leu-Gly-Ser-Lys (Su)-AMC as fluorogenic substrate incubated for 2 hrs in presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50629942(CHEMBL5424599)
Affinity DataIC50: 5.89E+3nMAssay Description:Competitive inhibition of human recombinant SIRT5 (34 to 269 residues) incubated for 2 hrs in presence of 33 uM of fluorogenic substrate Ac-Leu-Gly-S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50629942(CHEMBL5424599)
Affinity DataIC50: 6.74E+3nMAssay Description:Inhibition of human recombinant SIRT5 (34 to 269 residues) using Ac-Leu-Gly-Ser-Lys (Su)-AMC as fluorogenic substrate incubated for 2 hrs in presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50629942(CHEMBL5424599)
Affinity DataIC50: 1.42E+4nMAssay Description:Competitive inhibition of human recombinant SIRT5 (34 to 269 residues) incubated for 2 hrs in presence of 100 uM of fluorogenic substrate Ac-Leu-Gly-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50629942(CHEMBL5424599)
Affinity DataIC50: 2.19E+4nMAssay Description:Inhibition of recombinant SIRT1 (unknown origin) using Ac-Arg-Leu-Ile-Lys-(Ac) AMC as substrate in presence of NAD+More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50629942(CHEMBL5424599)
Affinity DataIC50: 2.96E+4nMAssay Description:Competitive inhibition of human recombinant SIRT5 (34 to 269 residues) incubated for 2 hrs in presence of 300 uM of fluorogenic substrate Ac-Leu-Gly-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50629942(CHEMBL5424599)
Affinity DataIC50: 1.36E+5nMAssay Description:Inhibition of human recombinant SIRT2 using Ac-Glu-Thr-Asp-Lys (Dec)-AM as substrate in presence of NAD+More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50629942(CHEMBL5424599)
Affinity DataIC50: 6.00E+5nMAssay Description:Inhibition of recombinant SIRT3 (unknown origin) using Ac-Arg-Leu-Ile-Lys-(Ac) AMC as substrate in presence of NAD+More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed