BDBM50629946 CHEMBL5420622

SMILES COc1cc(Nc2nc(NCCCNC(=S)NCCC(O)=O)nc(Nc3ccccc3Cl)n2)cc(OC)c1

InChI Key InChIKey=QESBWEAXMQUJOF-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50629946   

LigandPNGBDBM50629946(CHEMBL5420622)
Affinity DataIC50: 3.27E+3nMAssay Description:Inhibition of human recombinant SIRT5 (34 to 269 residues) using Ac-Leu-Gly-Ser-Lys (Su)-AMC as fluorogenic substrate incubated for 2 hrs in presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50629946(CHEMBL5420622)
Affinity DataIC50: 3.48E+3nMAssay Description:Inhibition of human recombinant SIRT5 (34 to 269 residues) using Ac-Leu-Gly-Ser-Lys (Su)-AMC as fluorogenic substrate incubated for 2 hrs in presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50629946(CHEMBL5420622)
Affinity DataIC50: 4.07E+3nMAssay Description:Inhibition of human recombinant SIRT5 (34 to 269 residues) using Ac-Leu-Gly-Ser-Lys (Su)-AMC as fluorogenic substrate incubated for 2 hrs in presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50629946(CHEMBL5420622)
Affinity DataIC50: 4.66E+3nMAssay Description:Inhibition of human recombinant SIRT5 (34 to 269 residues) using Ac-Leu-Gly-Ser-Lys (Su)-AMC as fluorogenic substrate incubated for 2 hrs in presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50629946(CHEMBL5420622)
Affinity DataIC50: 4.77E+3nMAssay Description:Inhibition of human recombinant SIRT5 (34 to 269 residues) using Ac-Leu-Gly-Ser-Lys (Su)-AMC as fluorogenic substrate incubated for 2 hrs in presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50629946(CHEMBL5420622)
Affinity DataIC50: 4.83E+3nMAssay Description:Inhibition of human recombinant SIRT5 (34 to 269 residues) using Ac-Leu-Gly-Ser-Lys (Su)-AMC as fluorogenic substrate incubated for 2 hrs in presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50629946(CHEMBL5420622)
Affinity DataIC50: 7.93E+3nMAssay Description:Competitive inhibition of human recombinant SIRT5 (34 to 269 residues) incubated for 2 hrs in presence of 11 uM of fluorogenic substrate Ac-Leu-Gly-S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50629946(CHEMBL5420622)
Affinity DataIC50: 1.43E+4nMAssay Description:Competitive inhibition of human recombinant SIRT5 (34 to 269 residues) incubated for 2 hrs in presence of 33 uM of fluorogenic substrate Ac-Leu-Gly-S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50629946(CHEMBL5420622)
Affinity DataIC50: 2.92E+4nMAssay Description:Competitive inhibition of human recombinant SIRT5 (34 to 269 residues) incubated for 2 hrs in presence of 100 uM of fluorogenic substrate Ac-Leu-Gly-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50629946(CHEMBL5420622)
Affinity DataIC50: 4.25E+4nMAssay Description:Competitive inhibition of human recombinant SIRT5 (34 to 269 residues) incubated for 2 hrs in presence of 300 uM of fluorogenic substrate Ac-Leu-Gly-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50629946(CHEMBL5420622)
Affinity DataIC50: 9.59E+4nMAssay Description:Inhibition of recombinant SIRT1 (unknown origin) using Ac-Arg-Leu-Ile-Lys-(Ac) AMC as substrate in presence of NAD+More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50629946(CHEMBL5420622)
Affinity DataIC50: 1.11E+5nMAssay Description:Inhibition of human recombinant SIRT2 using Ac-Glu-Thr-Asp-Lys (Dec)-AM as substrate in presence of NAD+More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50629946(CHEMBL5420622)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of recombinant SIRT3 (unknown origin) using Ac-Arg-Leu-Ile-Lys-(Ac) AMC as substrate in presence of NAD+More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed