BDBM50630102 CHEMBL5403777

SMILES Nc1ccccc1NC(=O)c1ccc(COc2ccc(CNC(=O)[C@@H]3CCCN3Cc3ccccc3)cc2)cc1

InChI Key InChIKey=FWWZNWCRXJQHCP-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50630102   

TargetHistone deacetylase 1(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50630102(CHEMBL5403777)
Affinity DataIC50: 113nMAssay Description:Inhibition of human recombinant HDAC1 using Ac-Leu-Gly-Lys(Ac)-AMC as substrate preincubated with enzyme for 30 mins followed by substrate addition a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50630102(CHEMBL5403777)
Affinity DataIC50: 192nMAssay Description:Inhibition of human recombinant HDAC2 using Ac-Leu-Gly-Lys(Ac)-AMC as substrate preincubated with enzyme for 30 mins followed by substrate addition a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50630102(CHEMBL5403777)
Affinity DataIC50: 387nMAssay Description:Inhibition of human recombinant HDAC3 using Ac-Leu-Gly-Lys(Ac)-AMC as substrate preincubated with enzyme for 30 mins followed by substrate addition a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50630102(CHEMBL5403777)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of C-terminal His-tagged human recombinant full length HDAC8 (1 to 377 residues) expressed in Sf9 cells using Ac-Leu-Gly-Lys(trifluoroAc)-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50630102(CHEMBL5403777)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of C-terminal FLAG-tagged human recombinant full length HDAC6 expressed in baculovirus expression system using Boc-Lys(Ac)-AMC as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetHistone deacetylase 4(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50630102(CHEMBL5403777)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of N-terminal GST-tagged/C-terminal His tagged human recombinant HDAC4 (627 to 1084 residues) expressed in baculovirus-infected Sf9 cells ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed