BDBM50630616 CHEMBL5412573

SMILES CCCCN(Cc1ccc(cc1)C(=O)NO)C(=O)CCCCn1cc(COc2cccc(Cc3cnc(NC(=O)CSc4nc(C)cc(C)n4)s3)c2)nn1

InChI Key InChIKey=VNFKTHQLIBPFNF-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50630616   

TargetHistone deacetylase 6(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50630616(CHEMBL5412573)
Affinity DataIC50: 43nMAssay Description:Inhibition of full length N-terminal GST-tagged human recombinant HDAC6 (1 to 1215 residues) expressed in Sf9 cells using ZMAL as fluorogenic substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50630616(CHEMBL5412573)
Affinity DataIC50: 43nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Guizhou Medical University

Curated by ChEMBL
LigandPNGBDBM50630616(CHEMBL5412573)
Affinity DataIC50: 320nMAssay Description:Inhibition of SIRT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Guizhou Medical University

Curated by ChEMBL
LigandPNGBDBM50630616(CHEMBL5412573)
Affinity DataIC50: 320nMAssay Description:Inhibition of recombinant human Sirt2 (56 to 356 residues) expressed in Escherichia coli BL21 Star (DE3) using ZMAL as substrate incubated for 4 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Guizhou Medical University

Curated by ChEMBL
LigandPNGBDBM50630616(CHEMBL5412573)
Affinity DataIC50: 560nMAssay Description:Inhibition of Sireal-TAMRA tracer binding to Sirt2 in HEK293 cells incubated for 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Guizhou Medical University

Curated by ChEMBL
LigandPNGBDBM50630616(CHEMBL5412573)
Affinity DataIC50: 880nMAssay Description:Inhibition of recombinant human Sirt2 (56 to 356 residues) expressed in Escherichia coli BL21 Star (DE3) mediated demyristoylation activity using pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Guizhou Medical University

Curated by ChEMBL
LigandPNGBDBM50630616(CHEMBL5412573)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Guizhou Medical University

Curated by ChEMBL
LigandPNGBDBM50630616(CHEMBL5412573)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of full length C-terminal 6His/FLAG-tagged human recombinant HDAC1 (1 to 482 residues) purified as tubulin complex expressed in Sf9 cells ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50630616(CHEMBL5412573)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of C-terminal His-tagged human recombinant HDAC3 (1 to 428 residues)/N-terminal GST tagged human NcoR2 (395 to 489 residues) expressed in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Guizhou Medical University

Curated by ChEMBL
LigandPNGBDBM50630616(CHEMBL5412573)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50630616(CHEMBL5412573)
Affinity DataIC50: 2.94E+3nMAssay Description:Inhibition of HDAC8 (unknown origin) using ZMTFAL as substrate incubated for 90 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Guizhou Medical University

Curated by ChEMBL
LigandPNGBDBM50630616(CHEMBL5412573)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Guizhou Medical University

Curated by ChEMBL
LigandPNGBDBM50630616(CHEMBL5412573)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of full length C-terminal FLAG-tagged human recombinant HDAC2 (1 to 488 residues) expressed in Sf9 cells using ZMAL as fluorogenic substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Guizhou Medical University

Curated by ChEMBL
LigandPNGBDBM50630616(CHEMBL5412573)
Affinity DataIC50: 9.70E+3nMAssay Description:Inhibition of recombinant human Sirt2 (56 to 356 residues) expressed in Escherichia coli BL21 Star (DE3) mediated demyristoylation activity using ZMM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed