BDBM50630734 CHEMBL5411127

SMILES COc1ccc2c(ccnc2c1)-c1ccc(CNS(N)(=O)=O)cc1

InChI Key InChIKey=UEJMNZDIQDULLP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50630734   

LigandPNGBDBM50630734(CHEMBL5411127)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant human ENPP1 using cGAMP as substrate assessed as inhibition of cGAMP hydrolysis preincubated for 5 to 10 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50630734(CHEMBL5411127)
Affinity DataIC50: 17nMAssay Description:Inhibition of C-terminal flag-tagged recombinant human ENPP1 (110 to 926 residues) extracted from HEK293F cells using p-Nph-5'-TMP as substrate by ab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50630734(CHEMBL5411127)
Affinity DataIC50: 340nMAssay Description:Inhibition of ENPP1 in human MDA-MB-231 cells using p-Nph-5'-TMP as substrate incubated for 15 min by absorbance based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 3(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50630734(CHEMBL5411127)
Affinity DataIC50: 1.27E+3nMAssay Description:Inhibition of recombinant human ENPP3 using p-Nph-5'-TMP as substrate by absorbance based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Mouse)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50630734(CHEMBL5411127)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal recombinant mouse ENPP2 (1 to 50 residues) extracted from HEK293F cells using p-Nph-5'-TMP as substrate by absorbance based ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed