BDBM50630756 CHEMBL5410824

SMILES Cc1ccc(-c2ncc3c(n2)N2CCOC[C@@]2(C)C(=O)N3[C@H]2CC[C@H](O)CC2)c2cc[nH]c12

InChI Key InChIKey=BYZCGCXGJTYMTH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50630756   

TargetSerine/threonine-protein kinase mTOR(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50630756BDBM50630756(CHEMBL5410824)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human GST-tagged mTOR (1360 to 2549 residues) expressed in insect cells using GFP-4E-BP1 as substrate incubated for 30 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTarget of rapamycin complex 2 subunit MAPKAP1(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50630756BDBM50630756(CHEMBL5410824)
Affinity DataIC50: 12nMAssay Description:Inhibition of mTORC2 in human PC-3 cells assessed as AKT phosphorylation at S473 residue in incubated for 1 hr by Alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed