BDBM50630757 CHEMBL5427469

SMILES Cc1cccc2c(-c3ncc4c(n3)N3CCOC[C@@]3(C)C(=O)N4[C@H]3CC[C@H](O)CC3)c[nH]c12

InChI Key InChIKey=ZSIRAWAQTMHYAU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50630757   

TargetTarget of rapamycin complex 2 subunit MAPKAP1(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50630757BDBM50630757(CHEMBL5427469)
Affinity DataIC50: 7nMAssay Description:Inhibition of mTORC2 in human PC-3 cells assessed as AKT phosphorylation at S473 residue in incubated for 1 hr by Alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Takeda California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50630757BDBM50630757(CHEMBL5427469)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human GST-tagged mTOR (1360 to 2549 residues) expressed in insect cells using GFP-4E-BP1 as substrate incubated for 30 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed