BDBM50631109 CHEMBL5398202

SMILES N#Cc1cccc(-c2c(Cl)[nH]c3ncnc(N4CC[C@@H](F)[C@@H](N)C4)c23)c1

InChI Key InChIKey=PPGUULSJUXLSJS-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50631109   

LigandChemical structure of BindingDB Monomer ID 50631109BDBM50631109(CHEMBL5398202)
Affinity DataKi:  1.70nMAssay Description:Inhibition of full length human recombinant HPK1 expressed in baculovirus-infected insect cells using 5-FAM-KRRALSSLRA-COOH peptide as substrate prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50631109BDBM50631109(CHEMBL5398202)
Affinity DataKi:  1.80nMAssay Description:Inhibition of HPK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50631109BDBM50631109(CHEMBL5398202)
Affinity DataKi:  1.80nMAssay Description:Inhibition of HPK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50631109BDBM50631109(CHEMBL5398202)
Affinity DataIC50: 36nMAssay Description:Inhibition of MAP4K3 (unknown origin) by by FRET based Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50631109BDBM50631109(CHEMBL5398202)
Affinity DataIC50: 154nMAssay Description:Inhibition of HPK1 (unknown origin) assessed as inhibition of SLP-76 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50631109BDBM50631109(CHEMBL5398202)
Affinity DataIC50: 154nMAssay Description:Inhibition of HPK1 in human Jurkat cells assessed as reduction in SLP76 phosphorylation pretreated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50631109BDBM50631109(CHEMBL5398202)
Affinity DataIC50: 154nMAssay Description:Inhibition of HPK1 (unknown origin) assessed as inhibition of SLP76 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed