BDBM50631167 CHEMBL5397861

SMILES CCN1CCC(CC1)n1cc(cn1)-c1cc(c(C#N)c(n1)N1CC[C@@H]1C)C(F)(F)F

InChI Key InChIKey=RAXKFFVGWRKQCK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50631167   

TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50631167(CHEMBL5397861)
Affinity DataIC50: 4nMAssay Description:Inhibition of human KHK-A preincubated for 15 mins followed by substrate addition and measured after 20 mins in presence of ATP by Rapidfire MS analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50631167(CHEMBL5397861)
Affinity DataIC50: 6nMAssay Description:Inhibition of human KHK-C preincubated for 15 mins followed by substrate addition and measured after 20 mins in presence of ATP by Rapidfire MS analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50631167(CHEMBL5397861)
Affinity DataIC50: 15nMAssay Description:Inhibition of KHK in human HepG2 cells incubated for 3 hrs by Rapidfire MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed