BDBM50631497 CHEMBL5417665
SMILES OC(=O)\C=C\c1nc(c(o1)-c1ccccc1)-c1ccccc1
InChI Key InChIKey=UJHITBMWYDKLJI-UHFFFAOYSA-N
Data 2 EC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 50631497
TargetNuclear receptor subfamily 4 group A member 2(Human)
Ludwig-Maximilians-University of Munich
Curated by ChEMBL
Ludwig-Maximilians-University of Munich
Curated by ChEMBL
Affinity DataKd: 600nMAssay Description:Binding affinity to human N-terminal His6 tagged Nurr1 LBD (362 to 598 residues) expressed in Escherichia coli BL21 (DE3)-R3-pRARE2 assessed as disso...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 4 group A member 1(Human)
Ludwig-Maximilians-University of Munich
Curated by ChEMBL
Ludwig-Maximilians-University of Munich
Curated by ChEMBL
Affinity DataIC50: 1.90E+3nMAssay Description:Inverse agonist activity at human Nur77 (358 to 598 residues) transfected in HEK293T cells incubated for 16 hrs by firefly/renilla based Dual-Glo luc...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 4 group A member 2(Human)
Ludwig-Maximilians-University of Munich
Curated by ChEMBL
Ludwig-Maximilians-University of Munich
Curated by ChEMBL
Affinity DataIC50: 3.00E+3nMAssay Description:Inverse agonist activity at Gal4-fused human full length Nurr1 monomer transfected in HEK293T cells cotransfected with pFR-Luc-NBRE incubated for 16 ...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 4 group A member 3(Human)
Ludwig-Maximilians-University of Munich
Curated by ChEMBL
Ludwig-Maximilians-University of Munich
Curated by ChEMBL
Affinity DataIC50: 3.80E+3nMAssay Description:Inverse agonist activity at human NOR-1 (393 to 626 residues) transfected in HEK293T cells incubated for 16 hrs by firefly/renilla based Dual-Glo luc...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 4 group A member 2(Human)
Ludwig-Maximilians-University of Munich
Curated by ChEMBL
Ludwig-Maximilians-University of Munich
Curated by ChEMBL
Affinity DataIC50: 4.00E+3nMAssay Description:Inverse agonist activity at Gal4-fused human full length Nurr1 heterodimer transfected in HEK293T cells cotransfected with pFR-Luc-DR5 incubated for ...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 4 group A member 2(Human)
Ludwig-Maximilians-University of Munich
Curated by ChEMBL
Ludwig-Maximilians-University of Munich
Curated by ChEMBL
Affinity DataIC50: 4.40E+3nMAssay Description:Inverse agonist activity at Gal4-fused human full length Nurr1 LBD transfected in HEK293T cells assessed as suppression of Nurr1 activation incubated...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 4 group A member 2(Human)
Ludwig-Maximilians-University of Munich
Curated by ChEMBL
Ludwig-Maximilians-University of Munich
Curated by ChEMBL
Affinity DataIC50: 5.30E+3nMAssay Description:Inverse agonist activity at Gal4-fused human full length Nurr1 homodimer transfected in HEK293T cells cotransfected with pFR-Luc-NurRE incubated for ...More data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-alpha(Human)
Ludwig-Maximilians-University of Munich
Curated by ChEMBL
Ludwig-Maximilians-University of Munich
Curated by ChEMBL
Affinity DataEC50: 1.30E+4nMAssay Description:Agonist activity at Gal4-fused human RXRalpha transfected in HEK293T cells incubated for 16 hrs by firefly/renilla based Dual-Glo luciferase assayMore data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-alpha(Human)
Ludwig-Maximilians-University of Munich
Curated by ChEMBL
Ludwig-Maximilians-University of Munich
Curated by ChEMBL
Affinity DataEC50: 1.30E+4nMAssay Description:Agonist activity at full length human RXR alpha expressed in HEK293T cells measured after 16 hrs by Dual-glo luciferase assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.31E+4nMAssay Description:Agonist activity at full length human RXR beta expressed in HEK293T cells measured after 16 hrs by Dual-glo luciferase assayMore data for this Ligand-Target Pair