BDBM50631721 CHEMBL5418423

SMILES NC(=O)CCn1cc(nn1)-c1ccc2ncnc(Nc3cc(O)c(F)cc3F)c2c1

InChI Key InChIKey=MKVJEWXMOVKCHS-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50631721   

TargetVascular endothelial growth factor receptor 2(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50631721(CHEMBL5418423)
Affinity DataIC50: 7nMAssay Description:Inhibition of VEGFR-2 (unknown origin) kinase activity using poly(Glu-Tyr) at 4:1 ratio as substrate in presence of ATP incubated for 60 mins by ELIS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50631721(CHEMBL5418423)
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant VEGFR-2 in the presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50631721(CHEMBL5418423)
Affinity DataIC50: 7nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50631721(CHEMBL5418423)
Affinity DataIC50: 51nMAssay Description:Inhibition of wild-type B-RAF (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50631721(CHEMBL5418423)
Affinity DataIC50: 51nMAssay Description:Inhibition of B-RAF V600E mutant (unknown origin) using magnesium acetate as substrate incubated for 40 mins in presence of [gamma33P]ATP by scintill...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50631721(CHEMBL5418423)
Affinity DataIC50: 57nMAssay Description:Inhibition of B-RAF (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50631721(CHEMBL5418423)
Affinity DataIC50: 57nMAssay Description:Inhibition of human recombinant B-Raf using magnesium acetate as substrate incubated for 40 mins in presence of [gamma33P]ATP by scintillation counte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50631721(CHEMBL5418423)
Affinity DataIC50: 73nMAssay Description:Inhibition of human recombinant EGFR using poly(Glu-Tyr) as substrate at 4:1 ratio in presence of ATP incubated for 60 mins by ELISA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50631721(CHEMBL5418423)
Affinity DataIC50: 73nMAssay Description:Inhibition of human EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50631721(CHEMBL5418423)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human recombinant C-Raf using Glu-Tyr-Met-Pro-Met-Glu as substrate incubated for 60 mins by radiometric kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50631721(CHEMBL5418423)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of C-RAF (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed