BDBM50631999 CHEMBL5396216

SMILES CCN1CCC(CN(C(=O)[C@@H]2CCN(Cc3ccccc3)C2)c2ccc(cc2)[As]2SCCS2)CC1

InChI Key InChIKey=KGPGKUQNWNDQJP-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50631999   

TargetPyruvate kinase PKM(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50631999(CHEMBL5396216)
Affinity DataIC50: 16nMAssay Description:Binding affinity to wild type FLAG-tagged PKM2 in human PA-1 cells measured for 72 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50631999(CHEMBL5396216)
Affinity DataIC50: 93nMAssay Description:Binding affinity to PKM2 C474S mutant in human PA-1 cells measured for 72 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50631999(CHEMBL5396216)
Affinity DataIC50: 129nMAssay Description:Binding affinity to PKM2 C474A mutant in human PA-1 cells measured for 72 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50631999(CHEMBL5396216)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PKM2 assessed as ATP production incubated for 10 mins in presence of beta-mercaptoethanol by Celltiter-glo luminescent analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50631999(CHEMBL5396216)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PKM2 assessed as ATP production incubated for 10 mins by Celltiter-glo luminescent analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed