BDBM50632570 CHEMBL5433451

SMILES CNc1cc(Nc2ccccc2OC)nc2c(cnn12)C(=O)N[C@@H]1CCN(C)C1=O

InChI Key InChIKey=YKGAFKZFWIEKPK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50632570   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632570(CHEMBL5433451)
Affinity DataIC50: 8nMAssay Description:Inhibition of TYK2 JH2 in human TF-1 cells assessed as reduction of IFNalpha induced STAT1 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632570(CHEMBL5433451)
Affinity DataIC50: 9nMAssay Description:Inhibition of IL-23 induced STAT3 phosphorylation in human KIT225 cells by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632570(CHEMBL5433451)
Affinity DataIC50: 45nMAssay Description:Inhibition of TYK2 JH2 (unknown origin) by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed