BDBM50632961 CHEMBL5431053

SMILES Cc1ccccc1C(=O)N2CCN(CC2)c3ccc4c(c3)cnnc4N

InChI Key InChIKey=COJCNHAXOZJCNU-UHFFFAOYSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50632961   

TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50632961(CHEMBL5431053)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human recombinant trypsin using Boc-phe-Ser-Arg-MCA as substrate pretreated with compound followed by substrate addition incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetProthrombin(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50632961(CHEMBL5431053)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human thrombin using L5-FAM/QXLTM 520 thrombin as substrate pretreated with compound followed by substrate addition incubated for 60 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetComplement C1r subcomponent(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50632961(CHEMBL5431053)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human recombinant N-terminal IgG tagged and C-terminal His tagged C1R (375 to 705 aa residues) expressed in HEK293 cells using Z-Gly-Ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetComplement factor D(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50632961(CHEMBL5431053)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human recombinant N-terminal IgG tagged and C-terminal His tagged factor D (26 to 253 aa residues) expressed in Expi293 cells using Z-L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetMannan-binding lectin serine protease 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50632961(CHEMBL5431053)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human recombinant N-terminal IgG tagged and C-terminal His tagged MASP2 (298 to 686 aa residues) expressed in Expi293 cells using Z-Gly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed