BDBM50632978 CHEMBL5417085

SMILES OC(=O)C1=C(CCC1)C(=O)Nc1ccc(cc1F)-c1cccc(OCC#C)c1

InChI Key InChIKey=BUJWDBSVEVFQDP-UHFFFAOYSA-N

Data  2 IC50  1 Kd  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50632978   

TargetNuclear receptor subfamily 4 group A member 2(Human)
Ludwig Maximilian University of Munich

Curated by ChEMBL
LigandPNGBDBM50632978(CHEMBL5417085)
Affinity DataEC50:  110nMAssay Description:Agonist activity at human Nurr1-LBD transfected in HEK293T cells co-transfected with pFR-Luc/pRL-SV40 assessed as transfection efficiency by measurin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetNuclear receptor subfamily 4 group A member 2(Human)
Ludwig Maximilian University of Munich

Curated by ChEMBL
LigandPNGBDBM50632978(CHEMBL5417085)
Affinity DataEC50:  220nMAssay Description:Agonist activity at human Nurr1 monomer NBRE transfected in HEK293T cells co-transfected with pFR-Luc/pRL-SV40 assessed as transfection efficiency by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetNuclear receptor subfamily 4 group A member 2(Human)
Ludwig Maximilian University of Munich

Curated by ChEMBL
LigandPNGBDBM50632978(CHEMBL5417085)
Affinity DataKd:  300nMAssay Description:Binding affinity to Nurr1-LBD (unknown origin) by Isothermal titration colorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetNuclear receptor subfamily 4 group A member 1(Human)
Ludwig Maximilian University of Munich

Curated by ChEMBL
LigandPNGBDBM50632978(CHEMBL5417085)
Affinity DataEC50:  1.40E+3nMAssay Description:Agonist activity at Nur77 (unknown origin) by Gal4 hybrid reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Ludwig Maximilian University of Munich

Curated by ChEMBL
LigandPNGBDBM50632978(CHEMBL5417085)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of human recombinant DHODH by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Rat)
Ludwig Maximilian University of Munich

Curated by ChEMBL
LigandPNGBDBM50632978(CHEMBL5417085)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of rat recombinant DHODH by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed