BDBM50633213 CHEMBL5421783

SMILES CN1CCN(Cc2ccc(NC(=O)[C@@H]3CCN(C3)c3ccc4ncc(-c5ccccn5)n4n3)cc2C(F)(F)F)CC1

InChI Key InChIKey=WYCSRUVPJUYDGP-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50633213   

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50633213(CHEMBL5421783)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50633213(CHEMBL5421783)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of TRKA (unknown origin) using ser/thr 06 peptide as substrate incubated for 1 hr in presence of ATP by FRET based Z'-lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetNT-3 growth factor receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50633213(CHEMBL5421783)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of TRKC (unknown origin) using ser/thr 06 peptide as substrate incubated for 1 hr in presence of ATP by FRET based Z'-lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50633213(CHEMBL5421783)
Affinity DataIC50: 6.40nMAssay Description:Inhibition of TRKB (unknown origin) using ser/thr 06 peptide as substrate incubated for 1 hr in presence of ATP by FRET based Z'-lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50633213(CHEMBL5421783)
Affinity DataIC50: 9.40nMAssay Description:Inhibition of TRKA G667C mutant (unknown origin) using ser/thr 06 peptide as substrate incubated for 1 hr in presence of ATP by FRET based Z'-lyte as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50633213(CHEMBL5421783)
Affinity DataIC50: 9.90nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50633213(CHEMBL5421783)
Affinity DataIC50: 71nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed