BDBM50633398 CHEMBL5422492

SMILES COc1ccc(\C=N\NC(=O)c2cnn(c2N)-c2ccc(cc2)S(N)(=O)=O)cc1

InChI Key InChIKey=RZVCBSGZKOFRJK-UHFFFAOYSA-N

Data  4 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50633398   

TargetCarbonic anhydrase 12(Human)
Damanhour University

Curated by ChEMBL
LigandPNGBDBM50633398(CHEMBL5422492)
Affinity DataKi:  22nMAssay Description:Binding affinity to human CA12 assessed as inhibition constant by stopped flow kinetic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetCarbonic anhydrase 9(Human)
Damanhour University

Curated by ChEMBL
LigandPNGBDBM50633398(CHEMBL5422492)
Affinity DataKi:  28nMAssay Description:Binding affinity to human CA9 assessed as inhibition constant by stopped flow kinetic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetCarbonic anhydrase 2(Human)
Damanhour University

Curated by ChEMBL
LigandPNGBDBM50633398(CHEMBL5422492)
Affinity DataKi:  44nMAssay Description:Binding affinity to human CA2 assessed as inhibition constant by stopped flow kinetic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetProstaglandin G/H synthase 2(Human)
Damanhour University

Curated by ChEMBL
LigandPNGBDBM50633398(CHEMBL5422492)
Affinity DataIC50: 150nMAssay Description:Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition measured after 2 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetCarbonic anhydrase 1(Human)
Damanhour University

Curated by ChEMBL
LigandPNGBDBM50633398(CHEMBL5422492)
Affinity DataKi:  279nMAssay Description:Binding affinity to human CA1 assessed as inhibition constant by stopped flow kinetic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetProtein-lysine 6-oxidase(Human)
Damanhour University

Curated by ChEMBL
LigandPNGBDBM50633398(CHEMBL5422492)
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of LOX (unknown origin) using arachidonic/linoleic acid as substrate preincubated for 5 mins followed by substrate addition measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetProstaglandin G/H synthase 1(Human)
Damanhour University

Curated by ChEMBL
LigandPNGBDBM50633398(CHEMBL5422492)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of COX-1 (unknown origin) using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition measured after 2 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed