BDBM50633590 CHEMBL5409600

SMILES c1cc2c(cc1Br)c(cn2CC(=O)NC3CCCCCC3)C(=O)C(F)(F)F

InChI Key InChIKey=LJWGWJLCHFYATI-UHFFFAOYSA-N

Data  7 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50633590   

TargetBifunctional epoxide hydrolase 2(Human)
Max Planck Institute of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50633590(CHEMBL5409600)
Affinity DataIC50: 6.70nMAssay Description:Inhibition of recombinant human sEH using fluorogenic PHOME as substrate measured after 10 sec by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetIndoleamine 2,3-dioxygenase 1(Human)
Max Planck Institute of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50633590(CHEMBL5409600)
Affinity DataIC50: 21nMAssay Description:Inhibition of IDO1 in human HCT-116 cells assessed as reduction in kynurenine level incubated for 48 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Max Planck Institute of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50633590(CHEMBL5409600)
Affinity DataIC50: 21nMAssay Description:Inhibition of IDO1 in MTAP knockout human HCT-116 cells assessed as reduction in kynurenine level incubated for 48 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Max Planck Institute of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50633590(CHEMBL5409600)
Affinity DataIC50: 29nMAssay Description:Inhibition of IDO1 in HEK293T cells assessed as reduction in kynurenine level incubated for 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Max Planck Institute of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50633590(CHEMBL5409600)
Affinity DataIC50: 40nMAssay Description:Inhibition of IDO1 in human BXPC-3 cells assessed as reduction in IFNgamma induced kynurenine level incubated for 48 hrs by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
Max Planck Institute of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50633590(CHEMBL5409600)
Affinity DataIC50: 68nMAssay Description:Inhibition of sEH in IFNgamma induced human HAP1 cells assessed as reduction in kynurenine productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetBifunctional epoxide hydrolase 2(Human)
Max Planck Institute of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50633590(CHEMBL5409600)
Affinity DataIC50: 159nMAssay Description:Displacement of tracer from NanoLuc fused sEH in HEK293T cells assessed as decrease in BRET ratio incubated for 5 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)