BDBM50633979 CHEMBL5400421

SMILES Nc1ccc(cc1NC(=O)c1ccc(cc1)-c1cn(C[S+]([O-])c2ccccc2)nn1)-c1cccs1

InChI Key InChIKey=BNXCWWNDNKACGS-UHFFFAOYSA-N

Data  1 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50633979   

TargetHistone deacetylase 1(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50633979(CHEMBL5400421)
Affinity DataIC50: 8.20nMAssay Description:Inhibition of full-length recombinant human C-terminal GST tagged HDAC1 expressed in Sf9 insect cells using aminoluciferin peptide substrate preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50633979(CHEMBL5400421)
Affinity DataIC50: 19nMAssay Description:Inhibition of full-length recombinant human C-terminal GST tagged HDAC2 expressed in Sf9 insect cells using aminoluciferin peptide substrate preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50633979(CHEMBL5400421)
Affinity DataKi:  22nMAssay Description:Inhibition of full-length recombinant human C-terminal GST tagged HDAC2 expressed in Sf9 insect cells assessed as inhibition constant using Ac-LGK(Ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50633979(CHEMBL5400421)
Affinity DataIC50: 4.45E+3nMAssay Description:Inhibition of full-length recombinant human C-terminal His-tagged HDAC8 expressed in Sf9 insect cells using aminoluciferin peptide substrate preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetNuclear receptor corepressor 1(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50633979(CHEMBL5400421)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human HDAC3/human GST-tagged NCOR1 (397 to 503 residues) using K(Ac)382 peptide substrate preincubated for 3 hrs followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed