BDBM50634158 CHEMBL5402615::US12599616, Example 2

SMILES CN(C)C\C=C\S(=O)(=O)NC(=O)Nc1c2CCCc2cc2CCCc12

InChI Key InChIKey=XFMDVDMGYHBHQV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50634158   

TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50634158BDBM50634158(CHEMBL5402615 | US12599616, Example 2)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of NLRP3 in human THP-1 cells assessed as reduction in IL-1beta production measured after 1 hrs in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetInterleukin-1 beta(Human)
Zydus Lifesciences

US Patent
LigandChemical structure of BindingDB Monomer ID 50634158BDBM50634158(CHEMBL5402615 | US12599616, Example 2)
Affinity DataIC50: 3.20nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2026
Entry Details
US Patent