BDBM50634558 CHEMBL5398714

SMILES COc1ccc(cc1Cl)-n1nc(C(=O)N2CCN3CCC2CC3)c2CCCc12

InChI Key InChIKey=ZEYAPPQZTLZNAY-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50634558   

TargetCeramide glucosyltransferase(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50634558(CHEMBL5398714 | US20250171467, Compound 19)
Affinity DataEC50:  0.300nMAssay Description:Inhibition of GCS activity in human A-375 cells using C6 ceramide as substrate pre-incubated for 30 mins followed by substrate addition and measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandPNGBDBM50634558(CHEMBL5398714 | US20250171467, Compound 19)
Affinity DataEC50:  0.300nMAssay Description:Using Promega's UDP-Glo Glycosyltransferase assay kit (Promega Corporation, Madison, WI, USA (Promega)), GCS activity was indirectly measured by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
US Patent