BDBM50634593 CHEMBL5426696

SMILES CC1(N)CCN(CC1)c1ncc(Sc2cccc(Cl)c2Cl)n2nccc12

InChI Key InChIKey=JNNODVFSEPFIIH-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50634593   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50634593(CHEMBL5426696)Copy SMILESCopy InChI

Affinity DataIC50: 208nMAssay Description:Allosteric inhibition of recombinant full length 6His-tagged SHP2 (2 to 527 residues) (unknown origin) expressed in Escherichia coli using DiFMUP as ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/22/2024
Entry Details
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TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Pfizer

Curated by ChEMBL

LigandBDBM50634593(CHEMBL5426696)Copy SMILESCopy InChI

Affinity DataIC50: 2.79E+3nMAssay Description:Inhibition of ERK1/2 phosphorylation at Thr202/Tyr204 residues in human KYSE520 cells incubated for 1 hrs by Western blot analysisMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/22/2024
Entry Details
Copy BDB DOIPubMed
Copy reaction URL