BDBM50634594 CHEMBL5433311

SMILES CC1(CCN(CC1)c2cnc3c(n2)ccc(n3)Sc4cccc(c4Cl)Cl)N

InChI Key InChIKey=ACCDLDCDCLNKCH-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50634594   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50634594(CHEMBL5433311)Copy SMILESCopy InChI

Affinity DataIC50: 47nMAssay Description:Allosteric inhibition of recombinant full length 6His-tagged SHP2 (2 to 527 residues) (unknown origin) expressed in Escherichia coli using DiFMUP as ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In Depth
Date in BDB:
12/22/2024
Entry Details
Copy BDB DOIPubMedPDB3D Structure (crystal)
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TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Pfizer

Curated by ChEMBL

LigandBDBM50634594(CHEMBL5433311)Copy SMILESCopy InChI

Affinity DataIC50: 1.07E+3nMAssay Description:Inhibition of ERK1/2 phosphorylation at Thr202/Tyr204 residues in human KYSE520 cells incubated for 1 hrs by Western blot analysisMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In Depth
Date in BDB:
12/22/2024
Entry Details
Copy BDB DOIPubMed
Copy reaction URL