BDBM50634611 CHEMBL5422905

SMILES C[C@H]1[C@H](C2(CCN(CC2)c3cnc4c(n3)ccc(n4)Sc5ccnc(c5Cl)N)CO1)N

InChI Key InChIKey=CNWPAKCFVFDYQN-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50634611   

TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Pfizer

Curated by ChEMBL

LigandBDBM50634611(CHEMBL5422905)Copy SMILESCopy InChI

Affinity DataIC50: 58nMAssay Description:Inhibition of ERK1/2 phosphorylation at Thr202/Tyr204 residues in human KYSE520 cells incubated for 1 hrs by Western blot analysisMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In Depth
Date in BDB:
12/22/2024
Entry Details
Copy BDB DOIPubMed
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TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50634611(CHEMBL5422905)Copy SMILESCopy InChI

Affinity DataIC50: 72nMAssay Description:Allosteric inhibition of recombinant full length 6His-tagged SHP2 (2 to 527 residues) (unknown origin) expressed in Escherichia coli using DiFMUP as ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In Depth
Date in BDB:
12/22/2024
Entry Details
Copy BDB DOIPubMedPDB3D Structure (crystal)
Copy reaction URL