BDBM50634620 CHEMBL5437468

SMILES COc1cnc2CC3(CCN(CC3)c3cnc4nc(Sc5ccnc(N)c5Cl)ccc4n3)[C@H](N)c2c1

InChI Key InChIKey=BBHOXURWAZHPOP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50634620   

LigandPNGBDBM50634620(CHEMBL5437468)
Affinity DataIC50: 8nMAssay Description:Inhibition of ERK1/2 phosphorylation at Thr202/Tyr204 residues in human KYSE520 cells incubated for 1 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandPNGBDBM50634620(CHEMBL5437468)
Affinity DataIC50: 60nMAssay Description:Allosteric inhibition of recombinant full length 6His-tagged SHP2 (2 to 527 residues) (unknown origin) expressed in Escherichia coli using DiFMUP as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed