BDBM50635775 CHEMBL5523360

SMILES COc1ccc(Nc2cc3c(cn2)n(C)c(=O)n3C2CCCC2)c(C)c1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50635775   

TargetDNA-dependent protein kinase catalytic subunit(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50635775(CHEMBL5523360)
Affinity DataIC50: 7.40nMAssay Description:Inhibition of human DNA-PK using EPPLSQEAFADLWK as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase 9(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50635775(CHEMBL5523360)
Affinity DataIC50: 193nMAssay Description:Inhibition of human JNK2 using 33P as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM50635775(CHEMBL5523360)
Affinity DataIC50: 226nMAssay Description:Inhibition of human PI3Kbeta using PI(4,5)P2:PS as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase 10(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50635775(CHEMBL5523360)
Affinity DataIC50: 308nMAssay Description:Inhibition of human JNK3 using 33P as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50635775(CHEMBL5523360)
Affinity DataIC50: 443nMAssay Description:Inhibition of human FMS using 33P as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM50635775(CHEMBL5523360)
Affinity DataIC50: 1.09E+3nMAssay Description:Inhibition of human PI3Kalpha using PI(4,5)P2:PS as substrate in presence of ATP by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM50635775(CHEMBL5523360)
Affinity DataIC50: 1.78E+3nMAssay Description:Inhibition of human PI3Kgamma using PI(4,5)P2:PS as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM50635775(CHEMBL5523360)
Affinity DataIC50: 3.92E+3nMAssay Description:Inhibition of human PI3Kdelta using PI(4,5)P2:PS as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine-protein kinase ATM(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50635775(CHEMBL5523360)
Affinity DataIC50: 4.05E+3nMAssay Description:Inhibition of human full length recombinant ATM using GST-cMyc-p53 as substrate by ELISA methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50635775(CHEMBL5523360)
Affinity DataIC50: 9.67E+3nMAssay Description:Inhibition of human mTOR in presence of ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed