BDBM50636024 CHEMBL5563563

SMILES N#Cc1cccc(CN2CCC(Nc3c(-c4cn[nH]c4)cnc4[nH]ccc34)CC2)c1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50636024   

TargetTyrosine-protein kinase JAK1(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50636024(CHEMBL5563563)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of recombinant JAK1 (unknown origin) using GFP-STAT1 as substrate incubated for 1 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Mouse)
University of South China

Curated by ChEMBL
LigandPNGBDBM50636024(CHEMBL5563563)
Affinity DataIC50: 230nMAssay Description:Inhibition of JAK1 in mouse Ba/F3-TEL-JAK1 cells assessed as inhibition of JAK1-driven cell growth incubated for 72 hrs by CCK8 assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50636024(CHEMBL5563563)
Affinity DataIC50: 845nMAssay Description:Inhibition of JAK2 (unknown origin) using GFP-STAT1 as substrate incubated for 1 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Mouse)
University of South China

Curated by ChEMBL
LigandPNGBDBM50636024(CHEMBL5563563)
Affinity DataIC50: 6.46E+3nMAssay Description:Inhibition of JAK2 in mouse Ba/F3-TEL-JAK2 cells assessed as inhibition of JAK1-driven cell growth incubated for 72 hrs by CCK8 assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50636024(CHEMBL5563563)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of TYK2 (unknown origin) using GFP-STAT1 as substrate incubated for 1 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Mouse)
University of South China

Curated by ChEMBL
LigandPNGBDBM50636024(CHEMBL5563563)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK3 in mouse Ba/F3-TEL-JAK3 cells assessed as inhibition of JAK1-driven cell growth incubated for 72 hrs by CCK8 assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50636024(CHEMBL5563563)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK3 (unknown origin) using GFP-STAT1 as substrate incubated for 1 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed