BDBM50636132 CHEMBL5558986

SMILES C=CC(=O)Nc1ccc(CCN2C(=O)N(c3cc(OC)cc(OC)c3)Cc3cnc(Nc4ccccc4NC(=O)C=C)nc32)cc1

InChI Key

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50636132   

TargetFibroblast growth factor receptor 4(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50636132(CHEMBL5558986)
Affinity DataIC50: 7nMAssay Description:Inhibition of human FGFR4 (445 to 753 residues) using preincubated for 30 mins followed by ATP plus poly (4:1 glu, tyr) addition and measured after 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 4(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50636132(CHEMBL5558986)
Affinity DataIC50: 29nMAssay Description:Inhibition of human FGFR4 C477A mutant using preincubated for 30 mins followed by ATP plus poly (4:1 glu, tyr) addition and measured after 30 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 4(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50636132(CHEMBL5558986)
Affinity DataIC50: 113nMAssay Description:Inhibition of human FGFR4 C552A mutant using preincubated for 30 mins followed by ATP plus poly (4:1 glu, tyr) addition and measured after 30 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 2(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50636132(CHEMBL5558986)
Affinity DataIC50: 150nMAssay Description:Inhibition of human FGFR2 (458 to 768 residues) using preincubated for 30 mins followed by ATP plus poly (4:1 glu, tyr) addition and measured after 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 3(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50636132(CHEMBL5558986)
Affinity DataIC50: 201nMAssay Description:Inhibition of human FGFR3 (450 to 758 residues) using preincubated for 30 mins followed by ATP plus poly (4:1 glu, tyr) addition and measured after 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50636132(CHEMBL5558986)
Affinity DataIC50: 420nMAssay Description:Inhibition of human FGFR1 (456 to 765 residues) using preincubated for 30 mins followed by ATP plus poly (4:1 glu, tyr) addition and measured after 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)