BDBM50636642 CHEMBL5542441
SMILES Cc1ccc2c(c1)NC(=O)[C@@]2(c1cn[nH]c1)c1cc(-c2ccc(C(=O)O)cc2C(=O)O)ccc1O
InChI Key
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 50636642
Affinity DataKd: 1.10E+3nMAssay Description:Binding affinity to C-terminally avi-tagged human IL-1 beta assessed as dissociation constant by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+3nMAssay Description:Antagonist activity at human recombinant His-tagged wild type IL-1 beta assessed as inhibition of IL-1 beta/Alexa 647 labeled human IL-1R1 (1 to 332)...More data for this Ligand-Target Pair
Affinity DataIC50: 5.30E+3nMAssay Description:Antagonist activity at human IL-1 beta assessed as inhibition of interaction of IL-1beta/IL-1R1 expressed in HEK293-Blue cells by measuring reduction...More data for this Ligand-Target Pair
Affinity DataIC50: 7.90E+3nMAssay Description:Antagonist activity at human IL-1 beta assessed as inhibition of interaction of IL-1 beta/IL-1R1 expressed in NHDF cells by measuring reduction in IL...More data for this Ligand-Target Pair
Affinity DataKi: <1.00E+4nMAssay Description:Displacement of (S)-3-(5-chloro-2-hydroxyphenyl)-3-hydroxy-6-(trifluoromethyl)indolin-2-one from biotinylated His6-tagged human IL-1 beta (117 to 269...More data for this Ligand-Target Pair