BDBM50637128 CHEMBL5523636

SMILES O=c1c2nn(C(F)F)cc2c2cc(F)c(Cl)cc2n1-c1cccnc1C(F)(F)F

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50637128   

TargetS-adenosylmethionine synthase isoform type-2(Human)
Suzhou Genhouse Bio

Curated by ChEMBL
LigandPNGBDBM50637128(CHEMBL5523636)
Affinity DataIC50: 47nMAssay Description:Inhibition of MAT2A (unknown origin) assessed as release of inorganic phosphate using ATP/L-methionine incubated for 30 mins by colorimetric phosphat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetS-adenosylmethionine synthase isoform type-2(Human)
Suzhou Genhouse Bio

Curated by ChEMBL
LigandPNGBDBM50637128(CHEMBL5523636)
Affinity DataIC50: 400nMAssay Description:Inhibition of MAT2A in MTAP-knock out human HCT-116 cells assessed as reduction in PRMT5-mediated symmetrical demethylation of arginine (SDMA) measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed