BDBM50637886 Culmerciclib

SMILES CC(C)c1c2cc(-c3nc(Nc4ccc(N5CCNCC5)cn4)ncc3F)ccc2nn1C

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50637886   

LigandPNGBDBM50637886(Culmerciclib)
Affinity DataIC50: 0.350nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM50637886(Culmerciclib)
Affinity DataIC50: 0.490nMAssay Description:Inhibition of CDK6/Cyclin D1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50637886(Culmerciclib)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 6(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50637886(Culmerciclib)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of CDK6 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 4(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50637886(Culmerciclib)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of CDK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM50637886(Culmerciclib)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin) transfected in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM50637886(Culmerciclib)
Affinity DataIC50: 13nMAssay Description:Inhibition of CDK9/cyclin T1 (unknown origin) in presence of 33P-gamma-ATP by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM50637886(Culmerciclib)
Affinity DataIC50: 35nMAssay Description:Inhibition of CDK5/p25 (unknown origin) in presence of 33P-gamma-ATP by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM50637886(Culmerciclib)
Affinity DataIC50: 60nMAssay Description:Inhibition of CDK6/Cyclin D1 (unknown origin) transfected in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM50637886(Culmerciclib)
Affinity DataIC50: 246nMAssay Description:Inhibition of CDK1/cyclin B (unknown origin) in presence of 33P-gamma-ATP by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM50637886(Culmerciclib)
Affinity DataIC50: 556nMAssay Description:Inhibition of CDK2/Cyclin E1 (unknown origin) transfected in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM50637886(Culmerciclib)
Affinity DataIC50: 2.09E+3nMAssay Description:Inhibition of CDK1/Cyclin E1 (unknown origin) transfected in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed