BDBM50637925 CHEMBL5559304
SMILES COc1cc(Nc2nccc(-c3cc(C(=O)N[C@@H](C)CN4CCC4)n(C)n3)n2)cc(OC)c1
InChI Key
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 17 hits for monomerid = 50637925
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human N-terminal His/GST-tagged SYK (356 to 635 residues) expressed in baculovirus infected Sf21 cells using KKKKKEQE-DEPEG...More data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Inhibition of SYK in mouse BaF3-TEL/SYK cells in absence of IL-3 stimulationMore data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Human)
Nerviano Medical Sciences S.r.l.
Curated by ChEMBL
Nerviano Medical Sciences S.r.l.
Curated by ChEMBL
Affinity DataIC50: 79nMAssay Description:Inhibition of PKR (unknown origin)More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Nerviano Medical Sciences S.r.l.
Curated by ChEMBL
Nerviano Medical Sciences S.r.l.
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of ROS1 (unknown origin)More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nerviano Medical Sciences S.r.l.
Curated by ChEMBL
Nerviano Medical Sciences S.r.l.
Curated by ChEMBL
Affinity DataIC50: 182nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 191nMAssay Description:Inhibition of ZAP70 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 239nMAssay Description:Inhibition of PKCbeta (unknown origin)More data for this Ligand-Target Pair
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Nerviano Medical Sciences S.r.l.
Curated by ChEMBL
Nerviano Medical Sciences S.r.l.
Curated by ChEMBL
Affinity DataIC50: 257nMAssay Description:Inhibition of MUSK (unknown origin)More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Human)
Nerviano Medical Sciences S.r.l.
Curated by ChEMBL
Nerviano Medical Sciences S.r.l.
Curated by ChEMBL
Affinity DataIC50: 450nMAssay Description:Inhibition of PKAalpha (unknown origin)More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha(Human)
Nerviano Medical Sciences S.r.l.
Curated by ChEMBL
Nerviano Medical Sciences S.r.l.
Curated by ChEMBL
Affinity DataIC50: 567nMAssay Description:Inhibition of PDGFRalpha (unknown origin)More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Human)
Nerviano Medical Sciences S.r.l.
Curated by ChEMBL
Nerviano Medical Sciences S.r.l.
Curated by ChEMBL
Affinity DataIC50: 697nMAssay Description:Inhibition of TRKA (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 3(Human)
Nerviano Medical Sciences S.r.l.
Curated by ChEMBL
Nerviano Medical Sciences S.r.l.
Curated by ChEMBL
Affinity DataIC50: 738nMAssay Description:Inhibition of MAP3K3 (unknown origin)More data for this Ligand-Target Pair
TargetHomeodomain-interacting protein kinase 1(Human)
Nerviano Medical Sciences S.r.l.
Curated by ChEMBL
Nerviano Medical Sciences S.r.l.
Curated by ChEMBL
Affinity DataIC50: 798nMAssay Description:Inhibition of HIPK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 802nMAssay Description:Inhibition of FER (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 980nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 7.83E+3nMAssay Description:Inhibition of SYK in IL-3 stimulated mouse BaF3-TEL/SYK cellsMore data for this Ligand-Target Pair