BDBM50637927 CHEMBL5542369

SMILES Cc1cccc(Nc2nccc(-c3cc(C(=O)N[C@@H](C)CN4CCC4)n(C)n3)n2)c1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50637927   

TargetTyrosine-protein kinase SYK(Human)
Nerviano Medical Sciences S.r.l.

Curated by ChEMBL
LigandPNGBDBM50637927(CHEMBL5542369)
Affinity DataIC50: 25nMAssay Description:Inhibition of recombinant human N-terminal His/GST-tagged SYK (356 to 635 residues) expressed in baculovirus infected Sf21 cells using KKKKKEQE-DEPEG...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Mus musculus)
Nerviano Medical Sciences S.r.l.

Curated by ChEMBL
LigandPNGBDBM50637927(CHEMBL5542369)
Affinity DataIC50: 90nMAssay Description:Inhibition of SYK in mouse BaF3-TEL/SYK cells in absence of IL-3 stimulationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Mus musculus)
Nerviano Medical Sciences S.r.l.

Curated by ChEMBL
LigandPNGBDBM50637927(CHEMBL5542369)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SYK in IL-3 stimulated mouse BaF3-TEL/SYK cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed