BDBM50638190 CHEMBL5561728

SMILES CN(C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)c1cccs1)C1CCCCC1)N(C#N)Cc1ccc(Cl)cc1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50638190   

TargetCathepsin B(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50638190(CHEMBL5561728)
Affinity DataKi:  5.90nMAssay Description:Inhibition of cathepsin B (unknown origin) using Z-Arg-Arg-pNA as substrate incubated for 60 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCathepsin S(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50638190(CHEMBL5561728)
Affinity DataKi:  7.90nMAssay Description:Inhibition of recombinant human cathepsin S using Z-Phe-Arg-AMC as substrate incubated for 60 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50638190(CHEMBL5561728)
Affinity DataKi:  13nMAssay Description:Inhibition of SARS-CoV2 main protease using Dabcyl-Lys-Thr-Ser-Ala-Val-Leu-Gln-Ser-Gly-Phe-Arg-Lys-Met-Glu-EDAN as substrate measured after 60 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50638190(CHEMBL5561728)
Affinity DataIC50: 18nMAssay Description:Inhibition of SARS-CoV2 main protease using Boc-Abu-Tle-Leu-Gln-AMC as substrate preincubated for 5 mins followed by enzyme addition and measured aft...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProcathepsin L(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50638190(CHEMBL5561728)
Affinity DataKi:  25nMAssay Description:Inhibition of human cathepsin L using Z-Phe-Arg-pNA as substrate incubated for 60 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed